What sealants do, and why the evidence is unusually strong
The pits and fissures on the biting surfaces of the back teeth are the single most vulnerable site for caries in the entire mouth. They are narrow, deep, and impossible to clean with a toothbrush bristle, which is wider than the fissure itself. Food debris and bacteria pack into these grooves and produce the acid that dissolves enamel. A pit-and-fissure sealant is a thin layer of flowable resin or glass-ionomer cement that is applied to these surfaces immediately after the tooth erupts, filling the grooves and creating a smooth, cleanable surface where bacteria can no longer accumulate. The tooth is not drilled, not anaesthetised, and not altered, it is simply protected.
The Cochrane systematic review on pit-and-fissure sealants for permanent teeth is one of the most robust pieces of preventive evidence in dentistry. Ahovuo-Saloranta and colleagues pooled the available randomised controlled trials and found that resin-based sealants reduce occlusal caries on permanent molars by 11 to 51 percentage points compared with no sealant, with the effect sustained over follow-up periods of up to four years [1]. The ADA evidence-based clinical practice guideline by Wright and colleagues confirmed these findings and recommended sealant placement on the pits and fissures of permanent molars in children and adolescents as a primary preventive strategy [2]. The Cochrane review on sealants for primary teeth found the same direction of effect, though with fewer included trials [3]. The message from all three sources is consistent: sealants work, the effect is large, and they are most effective when placed as soon as the tooth erupts, before the first cavity has a chance to start.